Event organiser Rebecca Milburn said: “Santa in the City started nine years ago with 450 Santas and has grown to become the incredible spectacle it is now.
“This is more than just a run – it’s a community coming together to make a difference.”
Sarcoma UK, which funds research into the condition, was the event’s official partner.
Its events manager, Louisa Morgan, said: “We’re turning Christmas cheer into a powerful platform for change.
“With 15 people being diagnosed with sarcoma every day in the UK, we urgently need to raise awareness of this devastating cancer and to transform that awareness into action.”
The National Brain Appeal was the event’s accessibility partner, ensuring it was inclusive.
The organisers want the public to get involved, by cheering on the runners on the final night.